SLC5A11

Across TCGA patient cohorts, SLC5A11 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A11-associated genes across cancer lineages are NDRG1_pT346, Cyclin-B1, and JNK_pT183_Y185. Each is linked with SLC5A11 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC5A11-to-partner and partner-to-SLC5A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDRG1_pT346 grouped by SLC5A11-low versus SLC5A11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A11→partner) and Y-score (partner→SLC5A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDRG1_pT346 →	-0.562	-1.584	.029	.035	3	4
UCEC	Cyclin-B1 →	+0.635	+3.700	<.001	.001	3	4
COAD	JNK_pT183_Y185 →	-0.396	-3.000	.003	.035	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.398	-3.153	.003	.018	3	3
UCEC	FoxM1 →	+0.219	+2.137	.013	.001	3	3
UCEC	Shc_pY317 →	-0.151	-1.765	.003	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

NDRG1_pT346 by SLC5A11 expression — SKCM

Explore this box plot interactively →