SLC5A11

Across TCGA pan-cancer cohorts, SLC5A11 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SLC5A11 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC5A11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC5A11 expression acts as an unfavorable survival marker, although some lineages such as READ and CESC show a favorable association.

LIHC, COAD, and READ are the cancer types where SLC5A11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	II,III,IV	0.614	0.804	.001	78	view →
COAD	OS	Tertile	All	0.523	0.820	.005	36	view →
READ	DFS	Tertile	III,IV	0.557	0.300	.012	30	view →
CESC	DFS	Quartile	IV	0.751	0.259	.016	16	view →
BRCA	OS	Quartile	IV	0.989	0.371	.011	16	view →
PRAD	DFS	Median	All	0.839	0.925	.002	16	view →
THYM	OS	Median	All	0.748	1.000	.009	11	view →
UCS	DFS	Quartile	II,III,IV	0.505	0.155	.025	10	view →
STAD	OS	Median	IV	0.648	0.171	.020	9	view →
CHOL	OS	Median	IV	0.208	0.948	.010	7	view →
ACC	DFS	Quartile	II,III,IV	0.428	0.929	.018	5	view →
THCA	OS	Tertile	II,III,IV	1.000	0.423	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SLC5A11–LIHC (OS)

Open the LIHC breakdown →