SLC4A8

Across TCGA patient cohorts, SLC4A8 mutation is significantly associated with the RNA expression of many other genes, with 4,140 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A8-associated genes across cancer lineages are TRAIP, KIF22, and DOLPP1. Each is linked with SLC4A8 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC4A8-to-partner and partner-to-SLC4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIP grouped by SLC4A8-low versus SLC4A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A8→partner) and Y-score (partner→SLC4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	+0.344	+1.169	.005	.006	3	5
LUAD	KIF22 →	+0.621	+3.620	<.001	.001	3	4
UCEC	DOLPP1 →	+0.519	+1.936	<.001	<.001	3	4
UCEC	MVD →	+0.402	+1.803	<.001	<.001	3	4
UCEC	E2F1 →	+0.682	+1.595	<.001	<.001	3	4
SKCM	RNASEH2A →	+0.361	+2.455	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,140 associations by consensus.

TRAIP by SLC4A8 expression — UCEC

Explore this box plot interactively →