SLC4A2

Across TCGA cell cohorts, SLC4A2 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC4A2-associated genes across cancer lineages are TCP11X1, TMEM52, and KHDC3L. Each is linked with SLC4A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC4A2-to-partner and partner-to-SLC4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X1 grouped by SLC4A2-low versus SLC4A2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A2→partner) and Y-score (partner→SLC4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TCP11X1 →	+0.003	+4.247	<.001	.004	3	2
LUNG_NSCLC_LUAD	TMEM52 →	+1.243	+3.243	<.001	.003	3	2
BLOOD_Leukemia	KHDC3L →	+0.137	+2.437	<.001	.005	3	2
LARGE_INTESTINE	GLIS3 →	-0.888	-3.169	.009	.009	3	2
LARGE_INTESTINE	TTC33 →	+0.583	+3.628	.004	<.001	3	2
LARGE_INTESTINE	ERAP2 →	+1.188	+2.502	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

TCP11X1 by SLC4A2 expression — BLOOD_Lymphoma

Explore this box plot interactively →