SLC4A11

Across TCGA patient cohorts, SLC4A11 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A11-associated genes across cancer lineages are ATM, TIGAR, and MEK1. Each is linked with SLC4A11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC4A11-to-partner and partner-to-SLC4A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC4A11-low versus SLC4A11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A11→partner) and Y-score (partner→SLC4A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.464	-1.986	<.001	.008	3	3
STAD	TIGAR →	+0.475	+3.000	.025	.034	3	2
UCEC	MEK1 →	+0.346	+2.415	.002	.002	3	2
SKCM	GATA3 →	-0.165	-1.874	.031	.049	3	2
UCEC	STAT3_pY705 →	-0.327	-2.087	<.001	.004	3	2
UCEC	eEF2 →	+0.273	+1.906	.013	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by SLC4A11 expression — UCEC

Explore this box plot interactively →