SLC4A11

Across TCGA pan-cancer cohorts, SLC4A11 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC4A11 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC4A11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC4A11 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

UVM, CESC, and SKCM are the cancer types where SLC4A11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.739	0.942	<.001	110	view →
CESC	OS	Tertile	III,IV	0.890	0.431	<.001	92	view →
SKCM	DFS	Quartile	All	0.626	0.796	<.001	54	view →
MESO	OS	Median	All	0.288	0.485	.001	33	view →
LUSC	DFS	Median	II,III,IV	0.483	0.319	.008	32	view →
LIHC	OS	Tertile	All	0.608	0.831	<.001	31	view →
OV	DFS	Median	III,IV	0.129	0.179	.007	30	view →
HNSC	DFS	Tertile	IV	0.748	0.592	.009	26	view →
STAD	DFS	Median	III,IV	0.711	0.476	.008	22	view →
KIRC	DFS	Tertile	II,III,IV	0.602	0.776	.008	20	view →
BLCA	OS	Tertile	II,III,IV	0.814	0.662	.004	19	view →
KIRP	DFS	Quartile	All	0.834	0.561	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC4A11–UVM (OS)

Open the UVM breakdown →