SLC4A11

Across TCGA cell cohorts, SLC4A11 mutation is significantly associated with the mutation status of many other genes, with 4,669 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC4A11-associated genes across cancer lineages are NES, CUBN, and DDX59. Each is linked with SLC4A11 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC4A11-to-partner and partner-to-SLC4A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NES grouped by SLC4A11-low versus SLC4A11-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A11→partner) and Y-score (partner→SLC4A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NES →	+4.807	+4.807	.008	.008	1	5
BLOOD_Leukemia	CUBN →	+2.176	+2.865	.001	.001	1	5
LARGE_INTESTINE	DDX59 →	+1.636	+1.963	.003	.003	1	5
LARGE_INTESTINE	SRCAP →	+1.626	+3.268	<.001	<.001	1	5
BONE	PLEKHG4 →	+5.000	+4.437	.007	.007	1	4
BLOOD_Leukemia	SNX25 →	+3.913	+3.465	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,669 associations by consensus.

NES by SLC4A11 expression — STOMACH

Explore this box plot interactively →