SLC49A4

Across TCGA pan-cancer cohorts, SLC49A4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC49A4 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLC49A4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC49A4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and OV are the cancer types where SLC49A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.877	.004	8	view →
CCRCC	DFS	Tertile	All	1.000	0.536	.012	7	view →
OV	DFS	Median	All	0.555	1.000	.028	4	view →
PDAC	OS	Median	II,III,IV	0.857	0.440	.024	3	view →
UCEC	DFS	Median	All	0.745	1.000	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC49A4–LSCC (DFS)

Open the LSCC breakdown →