SLC49A4

Across TCGA pan-cancer cohorts, SLC49A4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SLC49A4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLC49A4 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC49A4 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where SLC49A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC49A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.651	<.001	9	view →
COAD	Female	All	−0.872	<.001	7	view →
KIRC	Male	II,III,IV	−0.661	<.001	7	view →
LIHC	All	II,III,IV	+0.625	<.001	7	view →
BLCA	All	III,IV	+0.785	.004	6	view →
HNSC	All	All	+0.365	.004	6	view →
BRCA	Female	II,III,IV	+0.313	<.001	6	view →
KICH	All	All	−0.551	.004	5	view →
LUAD	Female	All	−0.357	<.001	5	view →
UCEC	All	II,III,IV	+0.820	.008	4	view →
CHOL	Female	All	+2.496	<.001	3	view →
READ	All	All	−1.006	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SLC49A4–THCA

Open the THCA breakdown →