SLC49A4

Across TCGA patient cohorts, SLC49A4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC49A4-associated genes across cancer lineages are EGFR, Ku80, and TIGAR. Each is linked with SLC49A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC49A4-to-partner and partner-to-SLC49A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SLC49A4-low versus SLC49A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC49A4→partner) and Y-score (partner→SLC49A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.192	-3.321	.022	.010	3	1
UCEC	Ku80 →	+0.257	+2.183	.038	.035	3	1
UCEC	TIGAR →	+0.175	+2.196	.029	.034	3	1
UCEC	Caspase-8 →	-0.296	-3.169	.024	.019	3	1
UCEC	Cyclin-B1 →	+0.663	+3.321	.024	.010	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR by SLC49A4 expression — UCEC

Explore this box plot interactively →