SLC49A4

Across TCGA cell cohorts, SLC49A4 mutation is significantly associated with the mutation status of many other genes, with 3,101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC49A4-associated genes across cancer lineages are SLC22A14, CDH2, and ERCC6. Each is linked with SLC49A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC49A4-to-partner and partner-to-SLC49A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A14 grouped by SLC49A4-low versus SLC49A4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC49A4→partner) and Y-score (partner→SLC49A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC22A14 →	+5.772	+5.772	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	CDH2 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	ERCC6 →	+5.392	+5.392	.004	.004	1	4
LUNG_NSCLC_LUAD	MAP2K7 →	+4.187	+5.000	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	KDM5A →	+5.392	+5.392	.004	.004	1	4
OVARY	PTPRN2 →	+4.415	+4.977	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

SLC22A14 by SLC49A4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →