SLC49A3

Across TCGA cell cohorts, SLC49A3 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC49A3-associated genes across cancer lineages are CYP2C19, USP14, and ASPN. Each is linked with SLC49A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC49A3-to-partner and partner-to-SLC49A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP2C19 grouped by SLC49A3-low versus SLC49A3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC49A3→partner) and Y-score (partner→SLC49A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP2C19 →	+0.023	+4.567	<.001	.001	3	2
LARGE_INTESTINE	USP14 →	+0.647	+3.087	.009	.006	3	1
LARGE_INTESTINE	ASPN →	+0.033	+2.648	.005	.008	3	1
LARGE_INTESTINE	RASGEF1C →	+0.227	+3.626	.001	.001	3	1
LARGE_INTESTINE	HAUS6 →	+0.893	+3.067	<.001	.009	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.090	+3.523	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

CYP2C19 by SLC49A3 expression — BLOOD_Leukemia

Explore this box plot interactively →