SLC49A3

Across TCGA pan-cancer cohorts, SLC49A3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SLC49A3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SLC49A3 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC49A3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

LUSC, COAD, and LUAD are the cancer types where SLC49A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC49A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−1.591	<.001	8	view →
COAD	Female	II,III,IV	−0.895	<.001	7	view →
LUAD	All	All	−0.382	<.001	7	view →
BRCA	Female	All	+0.449	.003	4	view →
KICH	All	All	+0.739	.029	3	view →
READ	Female	All	−1.220	.004	2	view →
CHOL	All	All	+1.246	.007	1	view →
LIHC	Female	All	+0.852	.013	1	view →
LIHC	Male	All	−0.580	.041	1	view →
THCA	All	III,IV	−0.368	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

SLC49A3–LUSC

Open the LUSC breakdown →