SLC46A3

Across TCGA pan-cancer cohorts, SLC46A3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SLC46A3 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC46A3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC46A3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC and LUAD are the cancer types where SLC46A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.884	0.400	.030	5	view →
LUAD	DFS	Quartile	All	0.836	0.440	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SLC46A3–CCRCC (OS)

Open the CCRCC breakdown →