SLC46A3

Across TCGA pan-cancer cohorts, SLC46A3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC46A3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC46A3 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC46A3 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LIHC, and LUSC are the cancer types where SLC46A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC46A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.975	<.001	11	view →
LIHC	Female	II,III,IV	−2.510	<.001	8	view →
LUSC	All	II,III,IV	−1.498	<.001	8	view →
THCA	Male	III,IV	−1.344	<.001	8	view →
LUAD	All	III,IV	−0.713	.004	7	view →
READ	Male	All	−1.396	.003	6	view →
KIRC	All	All	+0.275	.004	6	view →
CHOL	All	All	−2.489	<.001	5	view →
BRCA	All	All	−0.293	.001	4	view →
KICH	Male	All	−0.751	.017	3	view →
UCEC	All	All	−1.044	<.001	2	view →
PRAD	All	All	−0.466	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC46A3–COAD

Open the COAD breakdown →