SLC46A3

Across TCGA patient cohorts, SLC46A3 mutation is significantly associated with the RNA expression of many other genes, with 2,463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC46A3-associated genes across cancer lineages are PKM, RPL23AP82, and RPA2. Each is linked with SLC46A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC46A3-to-partner and partner-to-SLC46A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKM grouped by SLC46A3-low versus SLC46A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A3→partner) and Y-score (partner→SLC46A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKM →	+0.475	+2.058	<.001	<.001	3	3
UCEC	RPL23AP82 →	+0.432	+3.928	<.001	<.001	3	3
UCEC	RPA2 →	+0.366	+1.523	.003	.008	3	3
UCEC	PPCDC →	+0.428	+2.595	<.001	<.001	3	3
UCEC	CWC25 →	+0.302	+2.263	.008	.001	3	2
UCEC	UHRF1 →	+0.836	+3.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,463 associations by consensus.

PKM by SLC46A3 expression — UCEC

Explore this box plot interactively →