SLC46A3

Across TCGA patient cohorts, SLC46A3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC46A3-associated genes across cancer lineages are eIF4E, Notch1, and PDCD4. Each is linked with SLC46A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC46A3-to-partner and partner-to-SLC46A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC46A3-low versus SLC46A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A3→partner) and Y-score (partner→SLC46A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+2.392	.017	<.001	3	2
UCEC	Notch1 →	+0.122	+2.232	.014	.005	3	2
UCEC	PDCD4 →	-0.475	-2.105	.004	.017	3	2
UCEC	ATM →	-0.605	-2.321	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.087	-2.295	.013	.033	3	1
UCEC	eEF2 →	+0.294	+2.459	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by SLC46A3 expression — UCEC

Explore this box plot interactively →