SLC46A3

Across TCGA cell cohorts, SLC46A3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC46A3-associated genes across cancer lineages are CARTPT, C1orf141, and ARMH2. Each is linked with SLC46A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC46A3-to-partner and partner-to-SLC46A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARTPT grouped by SLC46A3-low versus SLC46A3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A3→partner) and Y-score (partner→SLC46A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CARTPT →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	C1orf141 →	+0.023	+4.371	.003	.005	3	1
LUNG_NSCLC_LUAD	ARMH2 →	+0.059	+5.189	<.001	<.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.053	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCL18 →	+0.129	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.030	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CARTPT by SLC46A3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →