SLC45A4

Across TCGA pan-cancer cohorts, SLC45A4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC45A4 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC45A4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC45A4 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where SLC45A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.413	1.000	.008	22	view →
CCRCC	DFS	Median	II,III,IV	0.435	1.000	.020	8	view →
GBM	DFS	Tertile	All	0.741	0.346	.024	3	view →
LUAD	DFS	Median	All	0.964	0.479	.030	3	view →
PDAC	DFS	Median	All	0.203	0.647	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC45A4–HNSC (DFS)

Open the HNSC breakdown →