SLC45A4

Across TCGA pan-cancer cohorts, SLC45A4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC45A4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLC45A4 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC45A4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where SLC45A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC45A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.936	<.001	9	view →
KICH	Male	All	−1.924	<.001	8	view →
LIHC	Female	II,III,IV	+1.499	<.001	8	view →
COAD	All	All	+0.279	.004	8	view →
KIRP	Male	All	−1.234	<.001	7	view →
KIRC	Male	II,III,IV	−0.938	<.001	7	view →
STAD	Male	II,III,IV	+1.532	<.001	6	view →
HNSC	All	All	+0.635	.001	6	view →
CHOL	Male	All	+2.980	<.001	5	view →
LUSC	All	III,IV	+1.173	.041	1	view →
BLCA	All	IV	−1.094	.046	1	view →
LUAD	Male	All	+0.369	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC45A4–THCA

Open the THCA breakdown →