SLC45A4

Across TCGA patient cohorts, SLC45A4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC45A4-associated genes across cancer lineages are Cyclin-E2, PCNA, and Caspase-7-cleavedD198. Each is linked with SLC45A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC45A4-to-partner and partner-to-SLC45A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SLC45A4-low versus SLC45A4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC45A4→partner) and Y-score (partner→SLC45A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.301	+2.832	.012	.034	3	4
UCEC	PCNA →	+0.144	+1.415	.034	.040	3	3
UCEC	Caspase-7-cleavedD198 →	+0.722	+2.115	<.001	<.001	3	3
UCEC	JNK2 →	+0.197	+2.026	.001	.016	3	2
COAD	E-Cadherin →	-0.786	-2.991	.016	.036	3	1
UCEC	EGFR_pY1068 →	-0.162	-1.584	.040	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-E2 by SLC45A4 expression — COAD

Explore this box plot interactively →