SLC45A4

Across TCGA cell cohorts, SLC45A4 mutation is significantly associated with the RNA expression of many other genes, with 291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC45A4-associated genes across cancer lineages are KRTAP4-8, MOGAT1, and RIC8B. Each is linked with SLC45A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC45A4-to-partner and partner-to-SLC45A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-8 grouped by SLC45A4-low versus SLC45A4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC45A4→partner) and Y-score (partner→SLC45A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP4-8 →	+0.680	+2.560	<.001	.008	3	2
BLOOD_Leukemia	MOGAT1 →	+0.028	+3.037	<.001	.001	3	2
LARGE_INTESTINE	RIC8B →	+0.463	+3.364	.009	.002	3	2
LARGE_INTESTINE	BTF3L4 →	+0.644	+3.169	.004	.009	3	2
LARGE_INTESTINE	BBS7 →	+0.631	+3.364	.002	.002	3	2
LARGE_INTESTINE	LARP1B →	+0.846	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 291 associations by consensus.

KRTAP4-8 by SLC45A4 expression — SKIN

Explore this box plot interactively →