SLC44A5

Across TCGA patient cohorts, SLC44A5 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC44A5-associated genes across cancer lineages are MSH6, FOXO3a_pS318_S321, and Dvl3. Each is linked with SLC44A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC44A5-to-partner and partner-to-SLC44A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by SLC44A5-low versus SLC44A5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC44A5→partner) and Y-score (partner→SLC44A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MSH6 →	+0.471	+3.331	.014	.005	3	2
LUAD	FOXO3a_pS318_S321 →	-0.112	-3.584	.021	.002	3	2
LUAD	Dvl3 →	+0.208	+2.476	.004	.011	2	3
UCEC	14-3-3_beta →	-0.069	-1.973	.039	.029	3	2
UCEC	eIF4E →	+0.208	+3.820	.003	<.001	3	2
UCEC	eIF4G →	+0.266	+2.222	.010	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

MSH6 by SLC44A5 expression — LUSC

Explore this box plot interactively →