SLC3A2

Across TCGA patient cohorts, SLC3A2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC3A2-associated genes across cancer lineages are ERK2, GSK-3_pS9, and Akt_pS473. Each is linked with SLC3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC3A2-to-partner and partner-to-SLC3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLC3A2-low versus SLC3A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC3A2→partner) and Y-score (partner→SLC3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.193	+3.700	.006	.001	3	2
UCEC	GSK-3_pS9 →	-0.394	-1.906	.007	.015	3	2
UCEC	Akt_pS473 →	-0.608	-1.847	.020	.008	3	2
UCEC	PCNA →	+0.212	+1.847	.007	.008	3	2
UCEC	PDCD4 →	-0.678	-2.700	<.001	.005	3	2
UCEC	BRCA2 →	-0.120	-3.574	.014	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ERK2 by SLC3A2 expression — UCEC

Explore this box plot interactively →