SLC39A8

Across TCGA pan-cancer cohorts, SLC39A8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC39A8 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC39A8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC39A8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, GBM, and LSCC are the cancer types where SLC39A8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.795	0.199	.024	8	view →
GBM	OS	Quartile	All	1.000	0.616	.040	4	view →
LSCC	DFS	Median	All	0.626	0.823	.026	2	view →
HNSC	DFS	Quartile	III,IV	0.877	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC39A8–PDAC (DFS)

Open the PDAC breakdown →