SLC39A8

Across TCGA pan-cancer cohorts, SLC39A8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC39A8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SLC39A8 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC39A8 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and LUSC are the cancer types where SLC39A8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC39A8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−3.256	<.001	11	view →
KICH	All	III,IV	−2.241	<.001	11	view →
LUSC	Female	II,III,IV	−4.135	<.001	9	view →
KIRC	All	All	+0.487	<.001	8	view →
UCEC	All	III,IV	+2.287	.002	6	view →
BLCA	Male	III,IV	+0.734	.021	6	view →
STAD	Male	All	+1.122	<.001	4	view →
CHOL	Female	All	−1.826	<.001	2	view →
READ	Female	All	−0.876	.038	2	view →
PRAD	All	All	+0.570	.001	2	view →
THCA	All	All	−0.260	.012	2	view →
ESCA	All	All	+1.607	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC39A8–LUAD

Open the LUAD breakdown →