SLC39A8

Across TCGA patient cohorts, SLC39A8 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A8-associated genes across cancer lineages are MSH2, C-Raf, and 14-3-3_beta. Each is linked with SLC39A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A8-to-partner and partner-to-SLC39A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by SLC39A8-low versus SLC39A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A8→partner) and Y-score (partner→SLC39A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.275	-2.558	.001	.010	3	2
UCEC	C-Raf →	+0.154	+2.807	.004	.003	3	2
UCEC	14-3-3_beta →	-0.132	-2.156	<.001	.003	3	1
UCEC	eIF4E →	+0.175	+2.169	.027	.003	3	1
UCEC	A-Raf_pS299 →	-0.124	-2.000	.005	.030	3	1
UCEC	ERK2 →	+0.177	+1.765	.014	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MSH2 by SLC39A8 expression — UCEC

Explore this box plot interactively →