SLC39A8

Across TCGA cell cohorts, SLC39A8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,915 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SLC39A8-associated GO terms across cancer lineages are Cellular detoxification of metal ion, Cobalt ion transport, and Detoxification of cadmium ion. Each is linked with SLC39A8 in more than 14 cancer types. Because this analysis shows association rather than direction, both SLC39A8-to-partner and partner-to-SLC39A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular detoxification of metal ion grouped by SLC39A8-low versus SLC39A8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A8→partner) and Y-score (partner→SLC39A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular detoxification of metal ion →	+1.099	+1.638	<.001	<.001	3	15
URINARY_TRACT	Cobalt ion transport →	+0.159	+1.334	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Detoxification of cadmium ion →	+0.351	+1.751	<.001	<.001	3	13
URINARY_TRACT	Cellular detoxification of cadmium ion →	+0.545	+1.079	.003	.002	3	13
URINARY_TRACT	Intracellular manganese ion homeostasis →	+0.231	+1.630	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Stress response to cadmium ion →	+0.351	+1.751	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,915 associations by consensus.

Cellular detoxification of metal ion by SLC39A8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →