SLC39A8

Across TCGA cell cohorts, SLC39A8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC39A8-associated genes across cancer lineages are ARGFX, C6orf118, and DEFA4. Each is linked with SLC39A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A8-to-partner and partner-to-SLC39A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by SLC39A8-low versus SLC39A8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A8→partner) and Y-score (partner→SLC39A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARGFX →	+0.035	+5.196	<.001	.005	3	1
LARGE_INTESTINE	C6orf118 →	+0.143	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ARGFX by SLC39A8 expression — OVARY

Explore this box plot interactively →