SLC39A7

Across TCGA cell cohorts, SLC39A7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,537 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SLC39A7-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, Multi-pass transmembrane protein insertion into ER membrane, and Endoplasmic reticulum to cytosol transport. Each is linked with SLC39A7 in more than 15 cancer types. Because this analysis shows association rather than direction, both SLC39A7-to-partner and partner-to-SLC39A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by SLC39A7-low versus SLC39A7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A7→partner) and Y-score (partner→SLC39A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cotranslational protein targeting to membrane →	+0.162	+0.884	<.001	<.001	3	16
LIVER	Multi-pass transmembrane protein insertion into ER membrane →	+0.142	+0.990	.007	.002	3	15
LUNG_SCLC	Endoplasmic reticulum to cytosol transport →	+0.152	+0.777	<.001	<.001	3	15
LUNG_SCLC	Retrograde protein transport, ER to cytosol →	+0.152	+0.777	<.001	<.001	3	15
BONE	Protein localization to endoplasmic reticulum →	+0.159	+0.802	<.001	<.001	3	14
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.159	+0.780	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,537 associations by consensus.

Cotranslational protein targeting to membrane by SLC39A7 expression — BONE

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