SLC39A7

Across TCGA pan-cancer cohorts, SLC39A7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC39A7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC39A7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC39A7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where SLC39A7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC39A7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.911	<.001	12	view →
BLCA	All	IV	+1.048	<.001	11	view →
LIHC	Female	II,III,IV	+1.694	<.001	9	view →
STAD	Male	III,IV	+1.253	<.001	9	view →
LUAD	Female	III,IV	+1.150	<.001	9	view →
THCA	Male	III,IV	−1.061	<.001	9	view →
UCEC	All	II,III,IV	+0.828	.007	6	view →
BRCA	All	III,IV	+0.812	<.001	6	view →
CHOL	Male	All	+2.170	<.001	5	view →
LUSC	All	All	+0.483	<.001	5	view →
PRAD	All	All	+0.427	.001	2	view →
KICH	All	All	−0.362	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC39A7–HNSC

Open the HNSC breakdown →