SLC39A2

Across TCGA patient cohorts, SLC39A2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC39A2-associated genes across cancer lineages are TIGAR, JNK_pT183_Y185, and MIG-6. Each is linked with SLC39A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC39A2-to-partner and partner-to-SLC39A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by SLC39A2-low versus SLC39A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC39A2→partner) and Y-score (partner→SLC39A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.239	+3.348	.002	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.204	-3.000	.020	.036	3	1
UCEC	MIG-6 →	+0.109	+2.183	.035	.035	3	1
UCEC	VHL →	-0.722	-3.000	.042	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.152	+3.019	<.001	.019	3	1
UCEC	eEF2 →	+0.651	+3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TIGAR by SLC39A2 expression — UCEC

Explore this box plot interactively →