SLC39A2

Across TCGA pan-cancer cohorts, SLC39A2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SLC39A2 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC39A2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC39A2 expression acts as an unfavorable survival marker, although some lineages such as SARC and KIRC show a favorable association.

UVM, KIRP, and SARC are the cancer types where SLC39A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.414	0.756	<.001	112	view →
KIRP	DFS	Median	All	0.749	1.000	<.001	80	view →
SARC	DFS	Tertile	All	0.500	0.281	<.001	36	view →
KIRC	DFS	Median	III,IV	0.805	0.678	.001	28	view →
OV	DFS	Median	IV	0.546	0.350	.009	24	view →
CESC	DFS	Tertile	All	0.872	0.735	.004	22	view →
PCPG	OS	Median	All	0.343	1.000	.004	18	view →
MESO	DFS	Tertile	IV	0.922	0.404	.008	15	view →
SCLC	OS	Median	IV	0.219	0.729	.003	13	view →
TGCT	DFS	Quartile	All	0.672	0.922	.011	12	view →
CHOL	DFS	Median	All	0.611	0.236	.022	12	view →
THCA	OS	Median	III,IV	0.331	1.000	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SLC39A2–UVM (DFS)

Open the UVM breakdown →