Across TCGA pan-cancer cohorts, SLC39A12-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SLC39A12-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where SLC39A12-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC39A12-AS1 is over-expressed in tumor.
ESCA and LIHC are the cancer types where SLC39A12-AS1 tumor–normal differential expression is most reproducible.