SLC38A5

Across TCGA pan-cancer cohorts, SLC38A5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SLC38A5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC38A5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SLC38A5 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where SLC38A5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC38A5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.794	<.001	11	view →
COAD	All	All	+0.672	<.001	8	view →
LSCC	Female	All	+1.177	<.001	7	view →
PDAC	Male	All	−1.987	<.001	6	view →
LUAD	All	All	+0.476	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SLC38A5–HNSC

Open the HNSC breakdown →