SLC38A4

Across TCGA patient cohorts, SLC38A4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A4-associated genes across cancer lineages are p70-S6K, RBM15, and Rictor_pT1135. Each is linked with SLC38A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A4-to-partner and partner-to-SLC38A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by SLC38A4-low versus SLC38A4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A4→partner) and Y-score (partner→SLC38A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p70-S6K →	+0.160	+1.662	.024	.009	3	2
UCEC	RBM15 →	+0.225	+3.000	.035	<.001	3	2
UCEC	Rictor_pT1135 →	-0.076	-1.584	.027	.009	3	2
UCEC	53BP1 →	+0.319	+3.700	.005	.001	3	2
SKCM	ETS-1 →	-0.257	-2.222	.001	.008	3	1
SKCM	GATA3 →	-0.140	-1.683	.014	.038	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

p70-S6K by SLC38A4 expression — SKCM

Explore this box plot interactively →