SLC38A4

Across TCGA pan-cancer cohorts, SLC38A4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC38A4 data layer compared with 5 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC38A4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC38A4 expression acts as an unfavorable survival marker, although some lineages such as LIHC and UCS show a favorable association.

LIHC, KIRP, and UVM are the cancer types where SLC38A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.807	0.594	<.001	64	view →
KIRP	OS	Median	II,III,IV	0.329	0.912	.006	50	view →
UVM	DFS	Median	All	0.492	0.953	<.001	43	view →
UCS	OS	Quartile	III,IV	0.699	0.261	.009	42	view →
OV	DFS	Median	All	0.501	0.579	.020	18	view →
THCA	OS	Tertile	All	1.000	0.902	.010	17	view →
UCEC	OS	Median	All	0.844	0.900	.018	16	view →
CESC	OS	Tertile	All	0.738	0.872	.008	14	view →
TGCT	DFS	Median	All	0.538	0.789	.002	14	view →
PRAD	DFS	Median	All	0.858	0.722	.016	12	view →
HNSC	DFS	Quartile	IV	0.696	0.469	.011	8	view →
DLBC	DFS	Median	II,III,IV	0.648	1.000	.036	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SLC38A4–LIHC (OS)

Open the LIHC breakdown →