SLC38A4

Across TCGA cell cohorts, SLC38A4 mutation is significantly associated with the mutation status of many other genes, with 5,248 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC38A4-associated genes across cancer lineages are KIF3C, DENND2B, and CPED1. Each is linked with SLC38A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC38A4-to-partner and partner-to-SLC38A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF3C grouped by SLC38A4-low versus SLC38A4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A4→partner) and Y-score (partner→SLC38A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KIF3C →	+2.942	+4.025	.009	.009	1	5
LARGE_INTESTINE	DENND2B →	+2.152	+2.787	.005	.005	1	5
LUNG_NSCLC_LUAD	CPED1 →	+3.263	+3.851	.005	.005	1	4
BLOOD_Leukemia	MYO7A →	+2.572	+4.129	.009	.009	1	4
UPPER_AERODIGESTIVE_TRACT	POLG →	+4.954	+4.392	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	INTS7 →	+5.539	+5.539	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,248 associations by consensus.

KIF3C by SLC38A4 expression — STOMACH

Explore this box plot interactively →