SLC38A1

Across TCGA patient cohorts, SLC38A1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A1-associated genes across cancer lineages are VHL, c-Kit, and C-Raf. Each is linked with SLC38A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A1-to-partner and partner-to-SLC38A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SLC38A1-low versus SLC38A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A1→partner) and Y-score (partner→SLC38A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.933	-2.321	<.001	.033	3	2
UCEC	c-Kit →	-0.198	-2.415	.035	.003	3	2
UCEC	C-Raf →	+0.180	+2.459	.001	.019	3	2
COAD	Caveolin-1 →	-0.753	-2.991	.041	.036	3	2
UCEC	eEF2 →	+0.375	+2.415	.009	.003	3	1
UCEC	EGFR →	-0.134	-2.459	.037	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

VHL by SLC38A1 expression — UCEC

Explore this box plot interactively →