SLC38A1

Across TCGA pan-cancer cohorts, SLC38A1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC38A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC38A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC38A1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where SLC38A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC38A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.191	<.001	12	view →
HNSC	All	III,IV	+1.107	<.001	12	view →
KIRP	All	III,IV	+1.483	<.001	11	view →
THCA	Male	II,III,IV	−1.593	<.001	10	view →
BLCA	All	III,IV	+1.429	<.001	10	view →
LIHC	Male	II,III,IV	+1.667	<.001	8	view →
LUSC	Male	II,III,IV	+1.731	<.001	7	view →
KICH	All	II,III,IV	+1.189	<.001	6	view →
BRCA	All	II,III,IV	+1.002	<.001	6	view →
CHOL	All	All	+4.195	<.001	5	view →
LUAD	All	All	+0.451	.005	3	view →
ESCA	All	All	+1.087	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC38A1–KIRC

Open the KIRC breakdown →