SLC35F4

Across TCGA pan-cancer cohorts, SLC35F4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC35F4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC35F4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC35F4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, COAD, and PRAD are the cancer types where SLC35F4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.136	0.612	.013	24	view →
COAD	DFS	Median	All	0.366	0.796	<.001	17	view →
PRAD	DFS	Median	All	0.200	0.775	.013	6	view →
LUSC	DFS	Median	III,IV	0.155	0.780	.010	6	view →
SKCM	DFS	Median	All	0.860	0.207	.014	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC35F4–HNSC (DFS)

Open the HNSC breakdown →