SLC35F4

Across TCGA pan-cancer cohorts, SLC35F4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC35F4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLC35F4 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC35F4 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

THCA, HNSC, and BRCA are the cancer types where SLC35F4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC35F4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.440	<.001	11	view →
HNSC	All	All	+0.026	.006	8	view →
BRCA	All	II,III,IV	+0.060	.004	6	view →
LUAD	All	All	+0.104	.003	4	view →
LIHC	Female	II,III,IV	+0.023	.008	3	view →
PRAD	All	All	−0.421	<.001	2	view →
UCEC	All	All	−0.362	.002	2	view →
KIRP	Male	II,III,IV	+0.140	.048	2	view →
KIRC	Male	III,IV	−0.063	.026	2	view →
CHOL	All	All	+0.051	.007	2	view →
STAD	All	All	+0.032	.022	2	view →
LUSC	All	All	+0.040	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC35F4–THCA

Open the THCA breakdown →