SLC30A6

Across TCGA pan-cancer cohorts, SLC30A6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC30A6 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLC30A6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC30A6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where SLC30A6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.541	0.946	.001	31	view →
LUAD	DFS	Median	All	0.768	0.429	.002	15	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.888	.010	13	view →
PDAC	DFS	Median	All	0.573	0.825	.011	9	view →
CCRCC	OS	Tertile	All	0.642	1.000	.015	4	view →
UCEC	OS	Median	All	0.981	0.909	.033	2	view →
GBM	OS	Tertile	All	0.697	0.913	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC30A6–LSCC (DFS)

Open the LSCC breakdown →