SLC30A6

Across TCGA pan-cancer cohorts, SLC30A6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC30A6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC30A6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC30A6 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where SLC30A6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC30A6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.025	<.001	12	view →
BLCA	Female	III,IV	+0.880	<.001	10	view →
LIHC	Female	II,III,IV	+1.020	<.001	9	view →
STAD	Male	II,III,IV	+0.796	<.001	7	view →
LUAD	Male	III,IV	+0.774	<.001	7	view →
KICH	Female	All	−1.292	<.001	6	view →
LUSC	Female	All	+0.762	<.001	6	view →
BRCA	All	II,III,IV	+0.318	<.001	6	view →
THCA	All	All	−0.267	.006	6	view →
CHOL	Female	All	+2.010	<.001	5	view →
COAD	Male	All	+0.504	<.001	5	view →
READ	All	III,IV	+0.804	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC30A6–HNSC

Open the HNSC breakdown →