SLC30A6

Across TCGA patient cohorts, SLC30A6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC30A6-associated genes across cancer lineages are JNK_pT183_Y185, A-Raf_pS299, and JNK2. Each is linked with SLC30A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC30A6-to-partner and partner-to-SLC30A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLC30A6-low versus SLC30A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC30A6→partner) and Y-score (partner→SLC30A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-2.584	.002	.010	3	2
UCEC	A-Raf_pS299 →	-0.158	-3.459	.001	.005	3	1
UCEC	JNK2 →	+0.235	+2.222	.005	.011	3	1
UCEC	Ku80 →	+0.233	+1.713	.020	.027	3	1
UCEC	MEK1 →	+0.470	+2.906	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.145	-3.302	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

JNK_pT183_Y185 by SLC30A6 expression — UCEC

Explore this box plot interactively →