SLC30A3

Across TCGA patient cohorts, SLC30A3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC30A3-associated genes across cancer lineages are ACC_pS79, ACC1, and Rad50. Each is linked with SLC30A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC30A3-to-partner and partner-to-SLC30A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by SLC30A3-low versus SLC30A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC30A3→partner) and Y-score (partner→SLC30A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.484	+3.459	<.001	.005	3	2
UCEC	ACC1 →	+0.592	+3.472	<.001	.002	3	2
UCEC	Rad50 →	-0.214	-1.807	.032	.027	3	2
UCEC	ATM →	-0.380	-1.807	.042	.027	3	2
UCEC	4E-BP1 →	+0.329	+2.199	.003	.033	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.321	.014	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ACC_pS79 by SLC30A3 expression — UCEC

Explore this box plot interactively →