SLC30A3

Across TCGA pan-cancer cohorts, SLC30A3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SLC30A3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC30A3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC30A3 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where SLC30A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC30A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.285	<.001	10	view →
LIHC	Female	All	+0.151	.001	6	view →
THCA	Male	All	+1.601	<.001	5	view →
KICH	Male	All	−0.150	<.001	5	view →
LUSC	All	All	+0.566	.001	4	view →
BLCA	Female	All	+0.286	.039	4	view →
KIRP	All	III,IV	+0.689	.019	2	view →
PRAD	All	All	−0.191	.018	2	view →
LUAD	All	All	+0.214	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SLC30A3–HNSC

Open the HNSC breakdown →