SLC26A5

Across TCGA patient cohorts, SLC26A5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A5-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and C-Raf. Each is linked with SLC26A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A5-to-partner and partner-to-SLC26A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC26A5-low versus SLC26A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A5→partner) and Y-score (partner→SLC26A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.672	+2.169	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.659	+3.169	<.001	<.001	3	3
COAD	C-Raf →	+0.201	+2.815	.012	.036	3	2
UCEC	p62 Lck ligand →	+0.296	+2.999	.003	<.001	3	2
UCEC	Shc_pY317 →	-0.164	-2.321	<.001	<.001	3	2
UCEC	TFRC →	+0.521	+2.906	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by SLC26A5 expression — UCEC

Explore this box plot interactively →