SLC26A5

Across TCGA pan-cancer cohorts, SLC26A5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC26A5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC26A5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC26A5 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where SLC26A5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC26A5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.283	.001	8	view →
BRCA	Female	All	−0.182	.024	4	view →
KIRC	All	All	−0.037	.020	3	view →
BRCA	All	IV	+0.700	.033	2	view →
PRAD	All	All	+0.465	<.001	2	view →
THCA	All	II,III,IV	−0.261	.026	2	view →
KIRP	Male	II,III,IV	−0.107	.021	2	view →
PAAD	Male	All	−0.070	.019	2	view →
LUAD	Female	II,III,IV	−0.265	.042	1	view →
LUSC	Male	All	−0.203	.012	1	view →
CHOL	Female	All	+0.130	.006	1	view →
COAD	Male	II,III,IV	+0.081	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

SLC26A5–HNSC

Open the HNSC breakdown →