SLC26A4

Across TCGA cell cohorts, SLC26A4 mutation is significantly associated with the RNA expression of many other genes, with 341 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC26A4-associated genes across cancer lineages are C9orf92, ADAM7, and CCDC185. Each is linked with SLC26A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A4-to-partner and partner-to-SLC26A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by SLC26A4-low versus SLC26A4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A4→partner) and Y-score (partner→SLC26A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	2
LARGE_INTESTINE	ADAM7 →	+0.002	+2.345	<.001	.007	3	2
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	LY6G6F →	+0.057	+5.169	<.001	<.001	3	1
SOFT_TISSUE	OR7E24 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 341 associations by consensus.

C9orf92 by SLC26A4 expression — SOFT_TISSUE

Explore this box plot interactively →